The research examines the role of using ICT to raise students’ achievement in Italian technical and professional schools. The hypothesis developed in this research is that students who obtain better learning results are those students who use ICT more than those students who are low performers. Data from the Programme for International Student Assessment (PISA) 2009 by OECD (Organisation for Economic Co-operation and Development) have been analyzed. The relationship between using ICT at school and students’ digital skills and attitudes has been analyzed by comparing the lowest performers and strong performers in reading literacy in Italian technical and professional schools. Results show that in Italian technical and professional schools, strong performers in reading literacy in PISA 2009 are more capable to do tasks at computer than low performers; however reading online and using ICT have greater positive effects towards achievement among low performers.